Pathology is considered to be the basis of disease. This block on Principles of Disease-1is, therefore, a vital one since its main objective is to provide students with sufficient knowledge of basic concepts of pathology and microbiology with some inputs from molecular biology and pharmacology. The need for this block to precede the integrated blocks on „systems‟ is, therefore, quite obvious. Basic concepts of processes like infections, inflammations, repair, hemodynamic disorders including thrombosis, embolism, infarction and shock as well as neoplasia, all of which cause most of the morbidity and mortality in the world, are introduced in the block to prepare the ground for the more in-depth study of the various organ systems of the body.